Pediatrics Adolescent Practice Exam

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In the pathophysiology of acne, which event occurs after excessive sebum production?

Immune response and inflammation

Colonization by Propionibacterium acnes

Alterations in follicular growth and differentiation

Excess sebum production sets the stage for acne by promoting abnormal desquamation and keratinocyte behavior inside the hair follicle. This leads to altered follicular growth and differentiation, causing a keratin plug and follicular occlusion (a comedone). That blocked follicle then becomes a niche for bacterial colonization and the inflammatory cascade, but the immediate next event after excess sebum is the changes in how the follicle grows and differentiates.

Excessive sebum production